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Home » Recipe Index » The BEST Mac and Cheese Meatloaf Casserole

The BEST Mac and Cheese Meatloaf Casserole

November 12, 2025 by Jenesis

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The BEST Mac and Cheese Meatloaf Casserole is a delightful dish that brings together the best of both worlds: hearty meatloaf and creamy mac and cheese. This comforting casserole is perfect for family dinners, gatherings, or even as a cozy meal on a chilly night. With its rich flavors and satisfying textures, it’s sure to become a favorite in your household.

Why You’ll Love This Recipe

  • Easy to Prepare: This recipe combines simple ingredients and straightforward steps, making it accessible for cooks of all levels.
  • Flavorful Layers: The combination of savory meatloaf and cheesy macaroni creates a delicious harmony that will please any palate.
  • Versatile Dish: Perfect for weeknight meals or special occasions, this casserole can easily adapt to suit your family’s tastes.
  • Crowd-Pleaser: Whether serving a small family or hosting guests, this dish is sure to impress everyone at the table.
  • Comforting Meal: Enjoy the warm and filling nature of this casserole, ideal for cozy nights in or potluck parties.

Tools and Preparation

Before diving into the cooking process, gather your tools for seamless preparation. Having everything ready will make cooking more enjoyable.

Essential Tools and Equipment

  • 9×13-inch baking dish
  • Mixing bowl
  • Medium saucepan
  • Whisk
  • Spoon or spatula

Importance of Each Tool

  • 9×13-inch baking dish: This size is perfect for layering your meatloaf and mac and cheese evenly while ensuring even baking.
  • Mixing bowl: A large bowl allows you to easily mix the meatloaf ingredients without spilling.
  • Medium saucepan: Essential for creating your creamy cheese sauce; a good saucepan ensures even heating.
  • Whisk: A whisk helps achieve a smooth cheese sauce by thoroughly combining ingredients without lumps.
The

Ingredients

A delicious and hearty casserole combining classic mac and cheese with a flavorful meatloaf layer, perfect for a comforting family meal.

For the Meatloaf Layer:

  • 1 ½ pounds ground beef
  • 1 cup breadcrumbs
  • 1 egg
  • ½ cup milk
  • 1 small onion, finely chopped
  • 1 teaspoon garlic powder
  • 1 teaspoon salt
  • ½ teaspoon black pepper
  • ½ cup barbecue sauce (for topping)

For the Mac and Cheese Layer:

  • 2 cups elbow macaroni
  • 2 tablespoons butter
  • 2 tablespoons all-purpose flour
  • 2 cups milk
  • 2 cups shredded cheddar cheese
  • ½ teaspoon salt
  • ¼ teaspoon paprika (optional)

How to Make The BEST Mac and Cheese Meatloaf Casserole

Step 1: Preheat the Oven

Preheat your oven to 375°F (190°C). Lightly grease your 9×13-inch baking dish to prevent sticking.

Step 2: Prepare the Meatloaf Layer

  1. In a large bowl, combine the following:
  2. ground beef
  3. breadcrumbs
  4. egg
  5. milk
  6. chopped onion
  7. garlic powder
  8. salt
  9. black pepper

  10. Mix until evenly combined.

  11. Press the meat mixture firmly into the bottom of the prepared dish to form an even base.
  12. Spread the barbecue sauce evenly over the top of the meat mixture.

Step 3: Bake the Meatloaf Layer

Bake in the preheated oven for 25 minutes, allowing the meat to start setting.

Step 4: Cook the Macaroni

While the meatloaf is baking, cook the elbow macaroni according to package directions. Drain well and set aside.

Step 5: Make the Cheese Sauce

  1. In a medium saucepan over medium heat, melt the butter.
  2. Whisk in flour and cook for about 1 minute while stirring constantly.
  3. Gradually add milk while whisking continuously until thickened into a smooth sauce.
  4. Remove from heat and stir in:
  5. shredded cheddar cheese
  6. salt
  7. paprika (if using)
  8. Mix until smooth and creamy.

Step 6: Combine Macaroni with Cheese Sauce

Fold cooked macaroni into the cheese sauce until well coated.

Step 7: Assemble Casserole

Carefully spoon the mac and cheese over the partially baked meatloaf layer, smoothing it into an even layer.

Step 8: Bake Again

Return to oven and bake for an additional 15-20 minutes or until golden brown and bubbly on top.

Step 9: Serve

Let rest for about 5 minutes before slicing into portions to serve. Enjoy!

How to Serve The BEST Mac and Cheese Meatloaf Casserole

Serving The BEST Mac and Cheese Meatloaf Casserole can elevate your family meal experience. Here are some delightful suggestions to enhance your dining occasion.

Pair it with a Fresh Salad

  • Garden Salad: A mix of leafy greens, tomatoes, cucumbers, and light vinaigrette provides a refreshing contrast to the richness of the casserole.
  • Caesar Salad: Crisp romaine lettuce with a creamy dressing complements the cheesy flavor and adds crunch.

Add Some Vegetables on the Side

  • Steamed Broccoli: Lightly steamed broccoli is nutritious and adds a pop of color to your plate.
  • Roasted Brussels Sprouts: Seasoned and roasted until crispy, these veggies offer a delicious bite alongside your casserole.

Include Bread Options

  • Garlic Breadsticks: Soft, buttery breadsticks brushed with garlic butter can enhance the overall comfort food vibe.
  • Cornbread Muffins: Slightly sweet cornbread muffins pair wonderfully with the savory flavors of the dish.

How to Perfect The BEST Mac and Cheese Meatloaf Casserole

To achieve perfection with The BEST Mac and Cheese Meatloaf Casserole, consider these helpful tips for flavor and texture.

  • Use Fresh Ingredients: Always opt for fresh ground beef and high-quality cheese for better taste.
  • Don’t Overcook the Pasta: Cook the macaroni al dente; it will continue cooking when combined with the hot cheese sauce.
  • Add Extra Cheese: For an even cheesier texture, sprinkle additional shredded cheddar on top before baking.
  • Season Generously: Adjust salt levels based on personal preference; season each layer for more depth of flavor.
  • Let it Rest: Allowing the casserole to sit for about five minutes after baking helps it set for easier slicing.

Best Side Dishes for The BEST Mac and Cheese Meatloaf Casserole

Pairing side dishes with The BEST Mac and Cheese Meatloaf Casserole can create a balanced meal. Here are some excellent options to consider.

  1. Garlic Roasted Asparagus: Toss asparagus in olive oil and garlic, then roast until tender for a vibrant side.
  2. Coleslaw: A crunchy, tangy slaw adds freshness that cuts through the richness of the casserole.
  3. Sweet Potato Fries: Crispy sweet potato fries offer a sweet contrast that complements the savory meatloaf layer.
  4. Baked Beans: Savory baked beans provide a hearty side that pairs perfectly with meatloaf flavors.
  5. Creamy Mashed Potatoes: Smooth mashed potatoes add comfort and pair well with both layers of this dish.
  6. Grilled Corn on the Cob: Brush corn with butter and grill it for a smoky sweetness that brightens up your plate.

Common Mistakes to Avoid

Many home cooks make simple mistakes that can affect the outcome of The BEST Mac and Cheese Meatloaf Casserole. Here are some common pitfalls and how to avoid them.

  • Skipping the Preheat: Failing to preheat your oven properly can lead to uneven cooking. Always preheat the oven to ensure your casserole bakes evenly.
  • Not Measuring Ingredients Accurately: Improper measurements can throw off the balance of flavors and textures. Use measuring cups and spoons for accuracy.
  • Overcooking the Macaroni: Cooking the macaroni too long before mixing it into the cheese sauce can result in mushy pasta. Follow package directions closely for al dente results.
  • Neglecting Barbecue Sauce Distribution: Spreading barbecue sauce unevenly may leave parts of the meatloaf bland. Make sure to spread it evenly for consistent flavor throughout.
  • Rushing the Cooling Time: Cutting into the casserole too soon can cause it to fall apart. Allow it to rest for five minutes for better slicing.
The

Storage & Reheating Instructions

Refrigerator Storage

  • Store leftovers in an airtight container for up to 3 days.
  • Allow the casserole to cool completely before sealing.

Freezing The BEST Mac and Cheese Meatloaf Casserole

  • Freeze in a freezer-safe container for up to 3 months.
  • Wrap tightly with plastic wrap or foil to prevent freezer burn.

Reheating The BEST Mac and Cheese Meatloaf Casserole

  • Oven: Preheat your oven to 350°F (175°C) and cover with foil. Bake for about 20-25 minutes or until heated through.
  • Microwave: Place a portion in a microwave-safe dish, cover, and heat in 1-minute intervals until hot.
  • Stovetop: Heat on low in a skillet, stirring occasionally until warmed through.

Frequently Asked Questions

Here are some frequently asked questions about The BEST Mac and Cheese Meatloaf Casserole.

Can I use ground turkey instead of beef?

Yes, ground turkey makes a great substitute if you prefer a leaner option. Just follow the same recipe instructions.

How do I customize The BEST Mac and Cheese Meatloaf Casserole?

Feel free to add vegetables like spinach or bell peppers into the meat mixture or mix different types of cheese into the mac and cheese layer.

Can I make this dish ahead of time?

Absolutely! You can prepare everything up until baking, then refrigerate overnight. Just increase baking time slightly if baked straight from the fridge.

What sides pair well with this casserole?

Green salads, steamed vegetables, or garlic bread complement this dish beautifully. They provide a fresh contrast to the richness of the casserole.

Final Thoughts

The BEST Mac and Cheese Meatloaf Casserole is a delightful fusion of comfort food that is perfect for family dinners. Its versatility allows you to customize ingredients based on what you have on hand or your personal preferences. Try this recipe today, and enjoy a hearty meal that everyone will love!

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The BEST Mac and Cheese Meatloaf Casserole

The BEST Mac and Cheese Meatloaf Casserole
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The BEST Mac and Cheese Meatloaf Casserole is a heartwarming dish that merges the rich flavors of savory meatloaf with creamy mac and cheese, creating a delightful meal for any occasion. This comforting casserole is perfect for family dinners, gatherings, or cozy nights in. The layers of tender ground beef, perfectly cooked elbow macaroni, and melty cheddar cheese come together to deliver a satisfying dining experience that everyone will love. Not only is it easy to prepare, but it also allows for customization to fit your family’s tastes. Get ready to indulge in this delicious comfort food that will become a staple in your home.

  • Author: Jenesis
  • Prep Time: 20 minutes
  • Cook Time: 45 minutes
  • Total Time: 1 hour 5 minutes
  • Yield: Serves 8
  • Category: Main
  • Method: Baking
  • Cuisine: American

Ingredients

Scale
  • 1 ½ pounds ground beef
  • 1 cup breadcrumbs
  • 1 egg
  • ½ cup milk
  • 1 small onion, finely chopped
  • 1 teaspoon garlic powder
  • 1 teaspoon salt
  • ½ teaspoon black pepper
  • ½ cup barbecue sauce (for topping)
  • 2 cups elbow macaroni
  • 2 tablespoons butter
  • 2 tablespoons all-purpose flour
  • 2 cups milk
  • 2 cups shredded cheddar cheese
  • ½ teaspoon salt
  • ¼ teaspoon paprika (optional)

Instructions

  1. Preheat oven to 375°F (190°C) and grease a 9×13-inch baking dish.
  2. In a mixing bowl, combine ground beef, breadcrumbs, egg, milk, chopped onion, garlic powder, salt, and black pepper. Mix well and press into the baking dish. Top with barbecue sauce.
  3. Bake for 25 minutes. Meanwhile, cook the macaroni according to package directions.
  4. In a saucepan over medium heat, melt butter and whisk in flour. Gradually add milk until thickened. Stir in cheddar cheese and seasonings until smooth.
  5. Combine cooked macaroni with the cheese sauce and spoon over the meatloaf layer.
  6. Bake again for an additional 15-20 minutes until golden brown.
  7. Let cool for 5 minutes before slicing and serving.

Nutrition

  • Serving Size: 1 serving
  • Calories: 350
  • Sugar: 3g
  • Sodium: 560mg
  • Fat: 18g
  • Saturated Fat: 8g
  • Unsaturated Fat: 10g
  • Trans Fat: 0g
  • Carbohydrates: 30g
  • Fiber: 2g
  • Protein: 20g
  • Cholesterol: 75mg

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